Hypergranulation tissue: evolution, control and potential elimination
AbstractGranulation tissue typically consists of an abundance of blood vessels mixed with fibrous connective tissue. Granulation tissue grows from the base of a wound and is able to fill the wound, facilitating eventual epithelialisation and wound closure. Continued wound healing will only take place once internal inter- and intracellular signalling notify keratinocytes and epithelial cells that the tissue is ready for their cellular migration.1-4 Prolonged stimulation of fibroplasia and angiogenesis results in hypergranulation, a potential problem for the wound healing process.
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