Hypergranulation tissue: evolution, control and potential elimination

  • Alan D Widgerow University of the Witwatersrand
  • Kathleen Leak Doncaster and Bassetlaw Foundation Trust Hospital
Keywords: pilonidal sinus, hypergranulation, wound dressing regimen


Granulation tissue typically consists of an abundance of blood vessels mixed with fibrous connective tissue. Granulation tissue grows from the base of a wound and is able to fill the wound, facilitating eventual epithelialisation and wound closure. Continued wound healing will only take place once internal inter- and intracellular signalling notify keratinocytes and epithelial cells that the tissue is ready for their cellular migration.1-4 Prolonged stimulation of fibroplasia and angiogenesis results in hypergranulation, a potential problem for the wound healing process.

Author Biographies

Alan D Widgerow, University of the Witwatersrand
MBBCh, FCS(SA Plast), MMed(Wits), FACS Emeritus Professor Department of Plastic Surgery University of the Witwatersrand and Irvine CA, USA
Kathleen Leak, Doncaster and Bassetlaw Foundation Trust Hospital
Sister Wound Care RN; BA (Hons) Department of Wound Care Doncaster and Bassetlaw Foundation Trust Hospital Doncaster South Yorkshire
General Review