Bioengineering and the diabetic foot ulcer

  • Alan David Widgerow University of California, irvine
Keywords: diabetic foot ulcer, skin substitutel scaffold, bioengiineering, vasculogenesis


Diabetic disease is increasing exponentially on a global scale. Diabetic foot ulcers (DFUs) are the leading cause of nontraumatic lower limb amputations. The pathophysiological events need to be considered when designing new interventions. Bioengineered skin substitutes (BSS) are accepted in the therapeutic armamentarium for DFU treatment. However, newer designs are likely to offer more targeted approaches to the disease process. This relates to the stimulation of vasculogenesis in particular. This can be achieved by using interactive scaffolds that stimulate endothelial progenitor cells to increase vascular endothelial growth factor production and reverse some of the damage that is caused by glycation end-products that are characteristic of diabetes.

Author Biography

Alan David Widgerow, University of California, irvine
MBBCh; FCS (Plast); MMed (Wits); FACS Clinical Professor Surgery (Plastic), Director Laboratory for Tissue Engineering & Regenerative Medicine Aesthetic & Plastic Surgery Institute, University of California, Irvine and Honorary Professor Plastic Surgery University of Witwatersrand South Africa
Basic Science Review