The role of advanced glycation end products in the hyperinflammatory response of diabetic wounds

  • Geoffrey Candy University of the Witwatersrand
  • Alan Gould University of the Witwatersrand
  • Cameron Naidoo University of the Witwatersrand
  • Deirdre Kruger University of the Witwatersrand
Keywords: Advanced Glycation End Products, Hyper-Inflammatory Response, Diabetic Wounds

Abstract

Chronic wounds are a frequent complication in diabetic patients and contribute significantly to morbidity and mortality. In the hyperglycaemic state, advanced glycation end products (AGEs) form, affecting collagen cross-linking, cytokine, nitric oxide and growth factor production and molecular signalling pathways. AGE receptors are upregulated and as it activates NF-kappaB, a host of inflammatory cytokines are expressed, exacerbating the self-sustaining inflammatory response seen in diabetic wounds. Therapeutic strategies include inhibiting the formation of AGEs, either directly or by inhibiting the formation of intermediates, and blocking the AGE receptor. A more complete understanding of the biology of the diabetic wound healing process is imperative in the development of successful treatment of diabetic wounds.

Author Biographies

Geoffrey Candy, University of the Witwatersrand
Senior Lecturer Department of Surgery Faculty of Health Sciences University of the Witwatersrand
Alan Gould, University of the Witwatersrand
Department of Surgery Faculty of Health Sciences University of the Witwatersrand
Cameron Naidoo, University of the Witwatersrand
Department of Surgery Faculty of Health Sciences University of the Witwatersrand
Deirdre Kruger, University of the Witwatersrand
Department of Surgery Faculty of Health Sciences University of the Witwatersrand
Published
2011-06-13
Section
General Review